Selective Purification

Our research team focuses on developing efficient assays for selectively purifying SARS-CoV-2 and Hepatitis viruses using oligo-coated magnetic nanoparticles. This innovative method targets the viruses’ unique genetic sequences, using the SNP nanoparticles’ magnetic properties to isolate them from complex matrixes.

Our approach offers significant advantages over traditional purification techniques for infectious disease diagnosis. Rapid and precise methods are crucial for pandemic response and preparedness. The increased sensitivity and specificity make it ideal for epidemiological studies and clinical diagnostics.

One key element of our method is the use of magnetic nanoparticles coated with synthetic oligos, which enable the selective purification of viral particles for accurate detection. This method is an alternative to host DNA depletion protocols, facilitating targeted genetic material purification and cost-effective sequencing projects. Nanopore sequencing determined the Limit of Detection (LOD) for SARS-CoV-2, and we could sequence viral particles at concentrations as low as 10-100 copies of genetic material.